Nicholas Katsanis, PhD

Jean and George W. Brumley Professor of Cell Biology and Pediatrics; Director, Center for Human Disease Modeling

Dr. Katsanis and his research team at the Center for Human Disease Modeling, including Dr. Christelle Golzio, have identified methods to query fundamental biological processes affected in children and infants with neurocognitive impairments, including autism. Their approach couples gene identification with modeling of genetic lesions in model organisms, including zebrafish and rodent models.  Their research is focused on understanding how genes causally implicated in neurodevelopmental disorders regulate neurogenesis, cell fate specification, migration and synaptogenesis.  They have capacity for high-throughput drug screening of novel compounds that can reduce or reverse behavioral and neurophysiological deficits associated with autism.