Scott Soderling, PhD

George Barth Geller Distinguished Professor of Molecular Biology; Chair, Department of Cell Biology

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Dr. Soderling received his Ph.D. at the University of Washington and did his postdoctoral work in the HHMI laboratory of Dr. John Scott.  As an HHMI postdoctoral fellow he uncovered a new neuronal signaling complex implicated in intellectual disability that facilitates the early development of synapses.  He was recruited to Duke University in 2006 and promoted to Associate Professor with tenure in 2013.  

Dr. Soderling is a reviewing editor for Frontiers in Neuroscience, serves as the Director of the Duke Transgenic Core Facility, and is the Director of Graduates Studies for the Dept. of Cell Biology.  His laboratory uses a suite of genetic, proteomic, and animal behavioral approaches to understand how abnormalities of synapses lead to behavioral deficits associated with disorders such as autism, schizophrenia, and intellectual disability. Dr. Soderling has co-authored a patent on his work and has published over 30 peer-reviewed scientific articles, several of which have been highlighted for their contributions to understanding brain disorders in editorials such as Nature Neuroscience, the LA Times, and NPR.  

Soderling lab

Representative Publications

Recent Publications:

Yan Z, Kim E, Datta D, Lewis DA, Soderling SH. (2016) Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? J Neurosci. 36(45):11411-11417.

Spence EF, Kanak DJ, Carlson BR, Soderling SH. (2016) The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing. J Neurosci. 14;36(37):9696-709.

Uezu A, Kanak DJ, Bradshaw TW, Soderblom EJ, Catavero CM, Burette AC, Weinberg RJ, Soderling SH. (2016) Identification of an elaborate complex mediating postsynaptic inhibition. Science. 9;353(6304):1123-9. 

Rossi MA, Li HE, Lu D, Kim IH, Bartholomew RA, Gaidis E, Barter JW, Kim N, Cai MT, Soderling SH, Yin HH (2016) A GABAergic nigrotectal pathway for coordination of drinking behavior. Nat Neurosci 19(5):742-8.

Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodrigues WS Jr., Pamukcu A, Enustun E, Ertuz Z, Scheiffle P, Soderling SH, Silver DL, Ji RR, Medina AE, Eroglu C (2016) Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell 164(1-2):183-96.

Spence EF, Soderling SH (2015) Actin Out: Regulation of the Synaptic Cytoskeleton. J Biol Chem. 290(48):28613-22.

Zuchero JB, Fu MM, Sloan SA, Ibrahim A, Olson A, Zaremba A, Dugas JC, Wienbar S, Caprariello AV, Kantor C, Leonoudakus D, Lariosa-Willingham K, Kronenberg G, Gertz K, Soderling SH, Miller RH, Barres BA. (2015) CNS Myelin Wrapping Is Driven by Actin Disassembly. Dev Cell.34(2):152-67.

Kim IH, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel WC, Weinberg RJ, Yin H, Soderling SH. (2015) Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. Nat Neurosci. 18(6):883-91.

Risher W.C., Patel S., Kim I.H., Uezu A., Bhagat S., Wilton D.K., Pilaz L.J., Singh Alvarado J., Calhan O.Y., Silver D.L., Stevens B., Calakos N., Soderling S.H., Eroglu C. (2014) Astrocytes refine cortical connectivity at dendritic spines. Elife 17;3

Kim IH, Wang H, Soderling SH, Yasuda R. (2014) Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. Elife. 8;3