Dr. Jiang’s research programs focus on understanding the molecular basis of autism by genetic and epigenetic analysis and modeling the pathophysiology of autism using genetically modified mutant mice and neurobiological techniques. They are actively working on the following projects: 1) Using next generation sequencing techniques, they are dissecting the molecular basis of autism by whole genome sequencing and epigenetic analysis techniques. 2) Modeling SHANK3 family genes causing autism by producing and characterizing Shank mutant mice. They are at the forefront of this line of research because of the unique mutant mice they have produced. 3) They are developing the treatment of autism by both pharmacological and neuromodulation approaches. First, they are testing whether the mGluR5 allosteric modulators can alleviate significant autistic behaviors in Shank autism mouse models. Second, they are exploring whether the neuromodulation by repetitive transcranial magnetic stimulation (rTMS) can be a therapeutic modality for autism in children.